Necrotizing enterocolitis (NEC) is one of the most common life-threatening gastrointestinal emergencies for the preterm infant. The survival rate for preterm infants after NEC has improved over the past two decades, but complications arising from medical and surgical intervention have produced many long term problems. Documented consequences of NEC include feeding intolerance and physical, developmental and cognitive problems. Bedside nurses are well positioned to detect early changes in the infant that may enable early treatment and reduce long-term complications.