Regulation of CD8(+) T cell functions by RARgamma.
Journal Article (Journal Article;Review)
Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARalpha and RARgamma are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARalpha and RARgamma function differently in thymocyte development and that RARgamma is required for both primary and secondary CD8(+) T cell immune responses.
- Gordy, C; Dzhagalov, I; He, Y-W
- February 2009
Volume / Issue
- 21 / 1
Start / End Page
- 2 - 7
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)