Regulation of CD8(+) T cell functions by RARgamma.

Journal Article (Journal Article;Review)

Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARalpha and RARgamma are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARalpha and RARgamma function differently in thymocyte development and that RARgamma is required for both primary and secondary CD8(+) T cell immune responses.

Full Text

Duke Authors

Cited Authors

  • Gordy, C; Dzhagalov, I; He, Y-W

Published Date

  • February 2009

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 2 - 7

PubMed ID

  • 18715802

Pubmed Central ID

  • PMC2615478

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2008.07.002


  • eng

Conference Location

  • England