Resolving response, decision, and strategic control: evidence for a functional topography in dorsomedial prefrontal cortex.

Journal Article (Journal Article)

The dorsomedial prefrontal cortex (DMPFC) plays a central role in aspects of cognitive control and decision making. Here, we provide evidence for an anterior-to-posterior topography within the DMPFC using tasks that evoke three distinct forms of control demands--response, decision, and strategic--each of which could be mapped onto independent behavioral data. Specifically, we identify three spatially distinct regions within the DMPFC: a posterior region associated with control demands evoked by multiple incompatible responses, a middle region associated with control demands evoked by the relative desirability of decision options, and an anterior region that predicts control demands related to deviations from an individual's preferred decision-making strategy. These results provide new insight into the functional organization of DMPFC and suggest how recent controversies about its role in complex decision making and response mapping can be reconciled.

Full Text

Duke Authors

Cited Authors

  • Venkatraman, V; Rosati, AG; Taren, AA; Huettel, SA

Published Date

  • October 2009

Published In

Volume / Issue

  • 29 / 42

Start / End Page

  • 13158 - 13164

PubMed ID

  • 19846703

Pubmed Central ID

  • PMC2801415

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.2708-09.2009


  • eng