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Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains.

Publication ,  Journal Article
Winn, M; Arendsen, D; Dodge, P; Dren, A; Dunnigan, D; Hallas, R; Hwang, K; Kyncl, J; Lee, YH; Plotnikoff, N; Young, P; Zaugg, H
Published in: Journal of Medicinal Chemistry
April 1976

Ten new delta6a,10a-THC analogs with arylalkyl side chains, one with a dimethylaminoalkyl side chain, and six heterocyclic delta6a,10a-THC analogs [8-substituted 5,5-dimethyl-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzo-pyrano[4,3-c]pyridines] were prepared. They showed pharmacological activity as analgesics, tranquilizers, antihypertensives, and hypnotics and as antisecretory, antiulcer, and antidiarrheal agents. The most potent compounds had either a 1-methyl-4-(4-fluorophenyl)butyl or a 1,2-dimethyl-4-(4-fluorophenyl)butyl side chain.

Duke Scholars

Published In

Journal of Medicinal Chemistry

ISSN

0022-2623

Publication Date

April 1976

Volume

19

Issue

4

Start / End Page

461 / 471

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Winn, M., Arendsen, D., Dodge, P., Dren, A., Dunnigan, D., Hallas, R., … Zaugg, H. (1976). Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. Journal of Medicinal Chemistry, 19(4), 461–471.
Winn, M., D. Arendsen, P. Dodge, A. Dren, D. Dunnigan, R. Hallas, K. Hwang, et al. “Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains.Journal of Medicinal Chemistry 19, no. 4 (April 1976): 461–71.
Winn M, Arendsen D, Dodge P, Dren A, Dunnigan D, Hallas R, et al. Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. Journal of Medicinal Chemistry. 1976 Apr;19(4):461–71.
Winn, M., et al. “Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains.Journal of Medicinal Chemistry, vol. 19, no. 4, Apr. 1976, pp. 461–71.
Winn M, Arendsen D, Dodge P, Dren A, Dunnigan D, Hallas R, Hwang K, Kyncl J, Lee YH, Plotnikoff N, Young P, Zaugg H. Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. Journal of Medicinal Chemistry. 1976 Apr;19(4):461–471.
Journal cover image

Published In

Journal of Medicinal Chemistry

ISSN

0022-2623

Publication Date

April 1976

Volume

19

Issue

4

Start / End Page

461 / 471

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry