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Induction chemotherapy: to use or not to use? That is the question.

Publication ,  Journal Article
Brizel, DM; Vokes, EE
Published in: Semin Radiat Oncol
January 2009

The intensification of radiation, induction chemotherapy, and concomitant chemoradiotherapy has been extensively investigated over the past 2 decades for the nonsurgical management of locally advanced, nonmetastatic squamous cell head and neck cancer (HNC). Concurrent chemoradiation has emerged as the standard of care, with the majority of its benefit resulting from improvements in locoregional disease control. Distant failure has become a more prominent problem in conjunction with these improvements. Concurrent chemotherapy provides suboptimal adjuvant treatment for distant disease. Multiagent induction chemotherapy holds more promise especially with the use of taxane-based regimens. Induction chemotherapy followed by concurrent chemoradiation (sequential chemoradiation) is now under investigation. The rationale and evidence supporting the choice to use or not to use a sequential program are discussed.

Duke Scholars

Published In

Semin Radiat Oncol

DOI

EISSN

1532-9461

Publication Date

January 2009

Volume

19

Issue

1

Start / End Page

11 / 16

Location

United States

Related Subject Headings

  • Taxoids
  • Remission Induction
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Humans
  • Head and Neck Neoplasms
  • Combined Modality Therapy
  • Clinical Trials as Topic
  • Chemotherapy, Adjuvant
  • Carcinoma, Squamous Cell
 

Citation

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MLA
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Brizel, D. M., & Vokes, E. E. (2009). Induction chemotherapy: to use or not to use? That is the question. Semin Radiat Oncol, 19(1), 11–16. https://doi.org/10.1016/j.semradonc.2008.09.003
Brizel, David M., and Everett E. Vokes. “Induction chemotherapy: to use or not to use? That is the question.Semin Radiat Oncol 19, no. 1 (January 2009): 11–16. https://doi.org/10.1016/j.semradonc.2008.09.003.
Brizel DM, Vokes EE. Induction chemotherapy: to use or not to use? That is the question. Semin Radiat Oncol. 2009 Jan;19(1):11–6.
Brizel, David M., and Everett E. Vokes. “Induction chemotherapy: to use or not to use? That is the question.Semin Radiat Oncol, vol. 19, no. 1, Jan. 2009, pp. 11–16. Pubmed, doi:10.1016/j.semradonc.2008.09.003.
Brizel DM, Vokes EE. Induction chemotherapy: to use or not to use? That is the question. Semin Radiat Oncol. 2009 Jan;19(1):11–16.
Journal cover image

Published In

Semin Radiat Oncol

DOI

EISSN

1532-9461

Publication Date

January 2009

Volume

19

Issue

1

Start / End Page

11 / 16

Location

United States

Related Subject Headings

  • Taxoids
  • Remission Induction
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Humans
  • Head and Neck Neoplasms
  • Combined Modality Therapy
  • Clinical Trials as Topic
  • Chemotherapy, Adjuvant
  • Carcinoma, Squamous Cell