Advances in understanding tissue regenerative capacity and mechanisms in animals.
Journal Article (Journal Article;Review)
Questions about how and why tissue regeneration occurs have captured the attention of countless biologists, biomedical engineers and clinicians. Regenerative capacity differs greatly across organs and organisms, and a range of model systems that use different regenerative strategies and that offer different technical advantages have been studied to understand regeneration. Making use of this range of systems and approaches, recent advances have allowed progress to be made in understanding several key issues that are common to natural regenerative events. These issues include: the determination of regenerative capacity; the importance of stem cells, dedifferentiation and transdifferentiation; how regenerative signals are initiated and targeted; and the mechanisms that control regenerative proliferation and patterning.
Full Text
Duke Authors
Cited Authors
- Poss, KD
Published Date
- October 2010
Published In
Volume / Issue
- 11 / 10
Start / End Page
- 710 - 722
PubMed ID
- 20838411
Pubmed Central ID
- PMC3069856
Electronic International Standard Serial Number (EISSN)
- 1471-0064
Digital Object Identifier (DOI)
- 10.1038/nrg2879
Language
- eng
Conference Location
- England