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Fgfs control homeostatic regeneration in adult zebrafish fins.

Publication ,  Journal Article
Wills, AA; Kidd, AR; Lepilina, A; Poss, KD
Published in: Development
September 2008

Adult teleost fish and urodele amphibians possess a spectacular ability to regenerate amputated appendages, based on formation and maintenance of progenitor tissue called a blastema. Although injury-induced, or facultative, appendage regeneration has been studied extensively, the extent to which homeostatic regeneration maintains these structures has not been examined. Here, we found that transgenic inhibition of Fgf receptors in uninjured zebrafish caused severe atrophy of all fin types within 2 months, revealing a requirement for Fgfs to preserve dermal bone, joint structures and supporting tissues. Appendage maintenance involved low-level expression of markers of blastema-based regeneration, focused in distal structures displaying recurrent cell death and proliferation. Conditional mutations in the ligand Fgf20a and the kinase Mps1, factors crucial for regeneration of amputated fins, also caused rapid, progressive loss of fin structures in otherwise uninjured animals. Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration.

Duke Scholars

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Published In

Development

DOI

ISSN

0950-1991

Publication Date

September 2008

Volume

135

Issue

18

Start / End Page

3063 / 3070

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Signal Transduction
  • Regeneration
  • Receptors, Fibroblast Growth Factor
  • Models, Biological
  • In Situ Hybridization
  • Homeostasis
  • Fibroblast Growth Factors
  • Extremities
 

Citation

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Wills, A. A., Kidd, A. R., Lepilina, A., & Poss, K. D. (2008). Fgfs control homeostatic regeneration in adult zebrafish fins. Development, 135(18), 3063–3070. https://doi.org/10.1242/dev.024588
Wills, Airon A., Ambrose R. Kidd, Alexandra Lepilina, and Kenneth D. Poss. “Fgfs control homeostatic regeneration in adult zebrafish fins.Development 135, no. 18 (September 2008): 3063–70. https://doi.org/10.1242/dev.024588.
Wills AA, Kidd AR, Lepilina A, Poss KD. Fgfs control homeostatic regeneration in adult zebrafish fins. Development. 2008 Sep;135(18):3063–70.
Wills, Airon A., et al. “Fgfs control homeostatic regeneration in adult zebrafish fins.Development, vol. 135, no. 18, Sept. 2008, pp. 3063–70. Pubmed, doi:10.1242/dev.024588.
Wills AA, Kidd AR, Lepilina A, Poss KD. Fgfs control homeostatic regeneration in adult zebrafish fins. Development. 2008 Sep;135(18):3063–3070.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

September 2008

Volume

135

Issue

18

Start / End Page

3063 / 3070

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Signal Transduction
  • Regeneration
  • Receptors, Fibroblast Growth Factor
  • Models, Biological
  • In Situ Hybridization
  • Homeostasis
  • Fibroblast Growth Factors
  • Extremities