Integrin alpha 6 regulates glioblastoma stem cells.

Published

Journal Article

Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for tumor maintenance, metastasis, and therapeutic resistance. Prospective identification and targeting of CSCs are therefore priorities for the development of novel therapeutic paradigms. Although CSC enrichment has been achieved with cell surface proteins including CD133 (Prominin-1), the roles of current CSC markers in tumor maintenance remain unclear. We examined the glioblastoma stem cell (GSC) perivascular microenvironment in patient specimens to identify enrichment markers with a functional significance and identified integrin alpha6 as a candidate. Integrin alpha6 is coexpressed with conventional GSC markers and enriches for GSCs. Targeting integrin alpha6 in GSCs inhibits self-renewal, proliferation, and tumor formation capacity. Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy.

Full Text

Duke Authors

Cited Authors

  • Lathia, JD; Gallagher, J; Heddleston, JM; Wang, J; Eyler, CE; Macswords, J; Wu, Q; Vasanji, A; McLendon, RE; Hjelmeland, AB; Rich, JN

Published Date

  • May 2010

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 421 - 432

PubMed ID

  • 20452317

Pubmed Central ID

  • 20452317

Electronic International Standard Serial Number (EISSN)

  • 1875-9777

International Standard Serial Number (ISSN)

  • 1934-5909

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2010.02.018

Language

  • eng