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Integrin alpha 6 regulates glioblastoma stem cells.

Publication ,  Journal Article
Lathia, JD; Gallagher, J; Heddleston, JM; Wang, J; Eyler, CE; Macswords, J; Wu, Q; Vasanji, A; McLendon, RE; Hjelmeland, AB; Rich, JN
Published in: Cell Stem Cell
May 7, 2010

Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for tumor maintenance, metastasis, and therapeutic resistance. Prospective identification and targeting of CSCs are therefore priorities for the development of novel therapeutic paradigms. Although CSC enrichment has been achieved with cell surface proteins including CD133 (Prominin-1), the roles of current CSC markers in tumor maintenance remain unclear. We examined the glioblastoma stem cell (GSC) perivascular microenvironment in patient specimens to identify enrichment markers with a functional significance and identified integrin alpha6 as a candidate. Integrin alpha6 is coexpressed with conventional GSC markers and enriches for GSCs. Targeting integrin alpha6 in GSCs inhibits self-renewal, proliferation, and tumor formation capacity. Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy.

Duke Scholars

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Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

May 7, 2010

Volume

6

Issue

5

Start / End Page

421 / 432

Location

United States

Related Subject Headings

  • Phenotype
  • Peptides
  • Neovascularization, Pathologic
  • Neoplastic Stem Cells
  • Mice, Inbred BALB C
  • Mice
  • Integrin alpha6
  • Humans
  • Glycoproteins
  • Glioblastoma
 

Citation

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Lathia, J. D., Gallagher, J., Heddleston, J. M., Wang, J., Eyler, C. E., Macswords, J., … Rich, J. N. (2010). Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell, 6(5), 421–432. https://doi.org/10.1016/j.stem.2010.02.018
Lathia, Justin D., Joseph Gallagher, John M. Heddleston, Jialiang Wang, Christine E. Eyler, Jennifer Macswords, Qiulian Wu, et al. “Integrin alpha 6 regulates glioblastoma stem cells.Cell Stem Cell 6, no. 5 (May 7, 2010): 421–32. https://doi.org/10.1016/j.stem.2010.02.018.
Lathia JD, Gallagher J, Heddleston JM, Wang J, Eyler CE, Macswords J, et al. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell. 2010 May 7;6(5):421–32.
Lathia, Justin D., et al. “Integrin alpha 6 regulates glioblastoma stem cells.Cell Stem Cell, vol. 6, no. 5, May 2010, pp. 421–32. Pubmed, doi:10.1016/j.stem.2010.02.018.
Lathia JD, Gallagher J, Heddleston JM, Wang J, Eyler CE, Macswords J, Wu Q, Vasanji A, McLendon RE, Hjelmeland AB, Rich JN. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell. 2010 May 7;6(5):421–432.
Journal cover image

Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

May 7, 2010

Volume

6

Issue

5

Start / End Page

421 / 432

Location

United States

Related Subject Headings

  • Phenotype
  • Peptides
  • Neovascularization, Pathologic
  • Neoplastic Stem Cells
  • Mice, Inbred BALB C
  • Mice
  • Integrin alpha6
  • Humans
  • Glycoproteins
  • Glioblastoma