Skip to main content
Journal cover image

Chordoid glioma: a case report and molecular characterization of five cases.

Publication ,  Journal Article
Horbinski, C; Dacic, S; McLendon, RE; Cieply, K; Datto, M; Brat, DJ; Chu, CT
Published in: Brain Pathol
July 2009

Chordoid gliomas are rare, slow-growing neoplasms of the anterior third ventricle. We reported a case of chordoid glioma in a 41-year-old man with obstructive hydrocephalus. Histologically, the tumor consisted of polygonal epithelioid cells admixed with elongated cells in a myxoid stroma. A prominent lymphoplasmacytic infiltrate was present. The tumor cells expressed glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, CD31, CD34, epidermal growth factor receptor (EGFR) and S100 but were negative for pankeratin and E-cadherin. The percentage of Ki67 positive cells was approximately 3%. Weak p53 immunoreactivity was seen in less than 10% of the cells. Array comparative genomic hybridization performed on this case, as well as on four other archived cases, showed losses at several loci. Fluorescence in situ hybridization (FISH) confirmed consistent genetic alterations at 9p21 and 11q13. These are the fifth through ninth reported cases of chordoid gliomas with molecular characterization suggesting a distinct genetic origin from other gliomas.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Brain Pathol

DOI

EISSN

1750-3639

Publication Date

July 2009

Volume

19

Issue

3

Start / End Page

439 / 448

Location

Switzerland

Related Subject Headings

  • Tomography, X-Ray Computed
  • Third Ventricle
  • Polymerase Chain Reaction
  • Neurosurgical Procedures
  • Neurology & Neurosurgery
  • Middle Aged
  • Microdissection
  • Male
  • In Situ Hybridization, Fluorescence
  • Immunohistochemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Horbinski, C., Dacic, S., McLendon, R. E., Cieply, K., Datto, M., Brat, D. J., & Chu, C. T. (2009). Chordoid glioma: a case report and molecular characterization of five cases. Brain Pathol, 19(3), 439–448. https://doi.org/10.1111/j.1750-3639.2008.00196.x
Horbinski, Craig, Sanja Dacic, Roger E. McLendon, Kathy Cieply, Michael Datto, Daniel J. Brat, and Charleen T. Chu. “Chordoid glioma: a case report and molecular characterization of five cases.Brain Pathol 19, no. 3 (July 2009): 439–48. https://doi.org/10.1111/j.1750-3639.2008.00196.x.
Horbinski C, Dacic S, McLendon RE, Cieply K, Datto M, Brat DJ, et al. Chordoid glioma: a case report and molecular characterization of five cases. Brain Pathol. 2009 Jul;19(3):439–48.
Horbinski, Craig, et al. “Chordoid glioma: a case report and molecular characterization of five cases.Brain Pathol, vol. 19, no. 3, July 2009, pp. 439–48. Pubmed, doi:10.1111/j.1750-3639.2008.00196.x.
Horbinski C, Dacic S, McLendon RE, Cieply K, Datto M, Brat DJ, Chu CT. Chordoid glioma: a case report and molecular characterization of five cases. Brain Pathol. 2009 Jul;19(3):439–448.
Journal cover image

Published In

Brain Pathol

DOI

EISSN

1750-3639

Publication Date

July 2009

Volume

19

Issue

3

Start / End Page

439 / 448

Location

Switzerland

Related Subject Headings

  • Tomography, X-Ray Computed
  • Third Ventricle
  • Polymerase Chain Reaction
  • Neurosurgical Procedures
  • Neurology & Neurosurgery
  • Middle Aged
  • Microdissection
  • Male
  • In Situ Hybridization, Fluorescence
  • Immunohistochemistry