Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.

Journal Article

The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133(+) cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1. These cells have a distinct expression profile that suggests increased proliferative capacity and decreased tendency to undergo apoptosis and differentiation. CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15(+) cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma.

Full Text

Duke Authors

Cited Authors

  • Read, T-A; Fogarty, MP; Markant, SL; McLendon, RE; Wei, Z; Ellison, DW; Febbo, PG; Wechsler-Reya, RJ

Published Date

  • February 3, 2009

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 135 - 147

PubMed ID

  • 19185848

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2008.12.016

Language

  • eng

Conference Location

  • United States