Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133(+) cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1. These cells have a distinct expression profile that suggests increased proliferative capacity and decreased tendency to undergo apoptosis and differentiation. CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15(+) cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma.
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Related Subject Headings
- Tumor Cells, Cultured
- Survival Rate
- Stem Cells
- Signal Transduction
- Recombinant Fusion Proteins
- Receptors, Cell Surface
- Peptides
- Patched Receptors
- Oncology & Carcinogenesis
- Neurons
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Cells, Cultured
- Survival Rate
- Stem Cells
- Signal Transduction
- Recombinant Fusion Proteins
- Receptors, Cell Surface
- Peptides
- Patched Receptors
- Oncology & Carcinogenesis
- Neurons