Analysis of DNA mismatch repair proteins in human medulloblastoma.

Journal Article (Journal Article)

During replication, the primary function of the eukaryotic DNA mismatch repair (MMR) system is to recognize and correct mismatched base pairs within the DNA helix. Deficiencies in MMR have been reported previously in cases of hereditary nonpolyposis colorectal cancer and sporadic tumors occurring in a variety of tissues including gliomas. Furthermore, recent evidence indicates that the MMR system may be involved in mediating therapeutic sensitivity to alkylating agents. In this study, 22 neoplastic tissue samples from 22 patients who underwent surgical resection for medulloblastoma, a common cerebellar tumor of childhood, were assayed for the presence or absence of MMR polypeptides using Western blot and immunohistochemical techniques. Results from these experiments indicate that the MMR system is not commonly deficient in medulloblastoma.

Full Text

Duke Authors

Cited Authors

  • Lee, SE; Johnson, SP; Hale, LP; Li, J; Bullock, N; Fuchs, H; Friedman, A; McLendon, R; Bigner, DD; Modrich, P; Friedman, HS

Published Date

  • June 1998

Published In

Volume / Issue

  • 4 / 6

Start / End Page

  • 1415 - 1419

PubMed ID

  • 9626457

International Standard Serial Number (ISSN)

  • 1078-0432


  • eng

Conference Location

  • United States