Treatment recommendations for primary extradural meningiomas.

Journal Article (Journal Article;Review)

Primary extradural meningiomas (PEMs) represent about 2% of all meningiomas and are often encountered by non-neurosurgeons. These lesions typically present as enlarging, painless, benign masses that can be surgically cured. Imaging is critical for defining involvement of adjacent structures; however, diagnosis depends on classic histologic patterns. Treatment for benign PEMs (WHO I) consists of resection with wide margins, whereas adjuvant therapy after resection of atypical (WHO II) or malignant (WHO III) PEMs should be considered. By using the collective experience from our comprehensive cancer center, including neuro-oncologists, neuroradiologists, and neurosurgeons, in addition to a complete literature review, the authors have established treatment guidelines not previously reported. This manuscript describes key features of these challenging tumors to aid in diagnosis, presents the largest published review of all reported PEMs (n = 163), and provides salient treatment guidelines to surgeons unfamiliar with these challenging tumors.

Full Text

Duke Authors

Cited Authors

  • Mattox, A; Hughes, B; Oleson, J; Reardon, D; McLendon, R; Adamson, C

Published Date

  • January 1, 2011

Published In

Volume / Issue

  • 117 / 1

Start / End Page

  • 24 - 38

PubMed ID

  • 20824719

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/cncr.25384


  • eng

Conference Location

  • United States