The evolution of gene regulatory interactions

Journal Article (Journal Article)

Changes in the timing and level at which genes are expressed are known to play an important role in evolution, but the mechanisms underlying changes in gene expression remain relatively obscure. Until quite recently, evolutionary biologists, like most biologists, tended to study single genes as isolated entities. These studies have added enormously to our understanding of biological evolution. But because gene regulation by its very nature involves interactions between two (or more) genes, researchers have missed a range of evolutionary phenomena that can be observed only at the level of networks of interacting genes. In this article, we consider the change in perspective that genomic technologiesparticularly the advent of large-scale platforms for DNA sequencing, genotyping, and measuring gene expressionare bringing to evolutionary biology. We focus specifically on how these technologies can and are being used to increase our understanding of how and why gene expression evolves. © 2010 by American Institute of Biological Sciences. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Garfield, DA; Wray, GA

Published Date

  • January 1, 2010

Published In

Volume / Issue

  • 60 / 1

Start / End Page

  • 15 - 23

International Standard Serial Number (ISSN)

  • 0006-3568

Digital Object Identifier (DOI)

  • 10.1525/bio.2010.60.1.6

Citation Source

  • Scopus