Omics meet networks - using systems approaches to infer regulatory networks in plants.

Published

Journal Article (Review)

Many genomic-scale datasets in plants have been generated over the last few years. This substantial achievement has led to impressive progress, including some of the most detailed molecular maps in any multicellular organism. Networks and pathways have been reconstructed using transcriptome, genome-wide transcription factor binding, proteome and metabolome data, and subsequently used to infer functional interactions among genes, proteins, and metabolites. However, more sophisticated systems biology approaches are needed to integrate different omics datasets. Ultimately, the integration of diverse and massive datasets into coherent models will improve our understanding of the molecular networks that underlie biological processes.

Full Text

Duke Authors

Cited Authors

  • Moreno-Risueno, MA; Busch, W; Benfey, PN

Published Date

  • April 2010

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 126 - 131

PubMed ID

  • 20036612

Pubmed Central ID

  • 20036612

Electronic International Standard Serial Number (EISSN)

  • 1879-0356

International Standard Serial Number (ISSN)

  • 1369-5266

Digital Object Identifier (DOI)

  • 10.1016/j.pbi.2009.11.005

Language

  • eng