Omics meet networks - using systems approaches to infer regulatory networks in plants.
Journal Article (Review;Journal Article)
Many genomic-scale datasets in plants have been generated over the last few years. This substantial achievement has led to impressive progress, including some of the most detailed molecular maps in any multicellular organism. Networks and pathways have been reconstructed using transcriptome, genome-wide transcription factor binding, proteome and metabolome data, and subsequently used to infer functional interactions among genes, proteins, and metabolites. However, more sophisticated systems biology approaches are needed to integrate different omics datasets. Ultimately, the integration of diverse and massive datasets into coherent models will improve our understanding of the molecular networks that underlie biological processes.
Full Text
Duke Authors
Cited Authors
- Moreno-Risueno, MA; Busch, W; Benfey, PN
Published Date
- April 2010
Published In
Volume / Issue
- 13 / 2
Start / End Page
- 126 - 131
PubMed ID
- 20036612
Pubmed Central ID
- PMC2862083
Electronic International Standard Serial Number (EISSN)
- 1879-0356
International Standard Serial Number (ISSN)
- 1369-5266
Digital Object Identifier (DOI)
- 10.1016/j.pbi.2009.11.005
Language
- eng