COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.

Published

Journal Article

The relationship between cognition and a functional polymorphism in the catechol-O-methlytransferase (COMT) gene, val108/158met, is one of debate in the literature. Furthermore, based on the dopaminergic differences associated with the COMT val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. To investigate these issues the current study aimed to 1) examine the effects of COMT genotype using a large sample of healthy individuals (n = 496-1218) and multiple cognitive measures, and using a subset of the sample (n = 22), 2) examine whether COMT genotype effects medial temporal lobe (MTL) and frontal activity during successful relational memory processing, and 3) investigate group differences in functional connectivity associated with successful relational memory processing. Results revealed no significant group difference in cognitive performance between COMT genotypes in any of the 19 cognitive measures. However, in the subset sample, COMT val homozygotes exhibited significantly decreased MTL and increased prefrontal activity during both successful relational encoding and retrieval, and reduced connectivity between these regions compared with met homozygotes. Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output.

Full Text

Duke Authors

Cited Authors

  • Dennis, NA; Need, AC; LaBar, KS; Waters-Metenier, S; Cirulli, ET; Kragel, J; Goldstein, DB; Cabeza, R

Published Date

  • March 2010

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 672 - 683

PubMed ID

  • 19641018

Pubmed Central ID

  • 19641018

Electronic International Standard Serial Number (EISSN)

  • 1460-2199

Digital Object Identifier (DOI)

  • 10.1093/cercor/bhp132

Language

  • eng

Conference Location

  • United States