Spectrum of a linearized amplitude equation for alternans in a cardiac fiber

Published

Journal Article

Under rapid periodic pacing, cardiac cells typically undergo a period-doubling bifurcation in which action potentials of short and long duration alternate with one another. If these action potentials propagate in a fiber, the short-long alternation may suffer reversals of phase at various points along the fiber, a phenomenon called (spatially) discordant alternans. Either stationary or moving patterns are possible. Using a weak approximation, Echebarria and Karma proposed an equation to describe the spatiotemporal dynamics of small-amplitude alternans in a class of simple cardiac models, and they showed that an instability in this equation predicts the spontaneous formation of discordant alternans. To study the bifurcation, they computed the spectrum of the relevant linearized operator numerically, supplemented with partial analytical results. In the present paper we calculate this spectrum with purely analytical methods in two cases where a small parameter may be exploited: (i) small dispersion or (ii) a long fiber. From this analysis we estimate the parameter ranges in which the phase reversals of discordant alternans are stationary or moving. © 2008 Society for Industrial and Applied Mathematics.

Full Text

Duke Authors

Cited Authors

  • Dai, S; Schaeffer, DG

Published Date

  • December 1, 2008

Published In

Volume / Issue

  • 69 / 3

Start / End Page

  • 704 - 719

International Standard Serial Number (ISSN)

  • 0036-1399

Digital Object Identifier (DOI)

  • 10.1137/070711384

Citation Source

  • Scopus