Cancer stem cells and survival pathways.


Journal Article (Review)

Gliomas and medulloblastomas are the most frequent malignant brain tumors in adult and children respectively. Although both tumors arise in the CNS, there is a significant difference in their therapeutic response. Medulloblastomas are relatively curable, while glioblastomas are basically incurable. During the last decade several reports have demonstrated the existence of cancer stem cells in brain tumors, their location and their response to treatment. We have recently described the therapeutic response of medulloblastomas to radiation in their native microenvironment, illustrating how p53 and Pi3K signaling pathways lead to the evasion of cell death by the nestin-expressing cells in the perivascular stem cell niche, even while the bulk of tumor succumbs to apoptosis.(1) It remains to be determined whether this mechanism of tumor resistance applies to the more complex stem-cell niche and tumor bulk of gliomas.

Full Text

Cited Authors

  • Hambardzumyan, D; Becher, OJ; Holland, EC

Published Date

  • May 2008

Published In

Volume / Issue

  • 7 / 10

Start / End Page

  • 1371 - 1378

PubMed ID

  • 18421251

Pubmed Central ID

  • 18421251

Electronic International Standard Serial Number (EISSN)

  • 1551-4005

International Standard Serial Number (ISSN)

  • 1538-4101

Digital Object Identifier (DOI)

  • 10.4161/cc.7.10.5954


  • eng