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Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2.

Publication ,  Journal Article
Bennett, SM; Mercer, JM; Noor, MAF
Published in: PloS one
June 2010

Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion in the RAD51-binding BRC-repeat array in the ancestor of Drosophila yakuba. In this study, we examine patterns of variation and evolution of the dmbrca2 BRC-repeat array within D. yakuba and its close relatives. We develop a model of how unequal crossing over may have produced the expanded form, but we also observe short repeat forms, typical of other species in the D. melanogaster group, segregating within D. yakuba and D. santomea. These short forms do not appear to be identical-by-descent, suggesting that the history of dmbrca2 in the D. melanogaster subgroup has involved repeat unit contractions resulting in homoplasious forms. We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species.

Duke Scholars

Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

June 2010

Volume

5

Issue

6

Start / End Page

e11006

Related Subject Headings

  • Sequence Homology, Amino Acid
  • Polymerase Chain Reaction
  • Phylogeny
  • Neoplasms
  • Molecular Sequence Data
  • Humans
  • Genetic Predisposition to Disease
  • Genes, BRCA2
  • General Science & Technology
  • Drosophila
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bennett, S. M., Mercer, J. M., & Noor, M. A. F. (2010). Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. PloS One, 5(6), e11006. https://doi.org/10.1371/journal.pone.0011006
Bennett, Sarah M., John M. Mercer, and Mohamed A. F. Noor. “Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2.PloS One 5, no. 6 (June 2010): e11006. https://doi.org/10.1371/journal.pone.0011006.
Bennett, Sarah M., et al. “Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2.PloS One, vol. 5, no. 6, June 2010, p. e11006. Epmc, doi:10.1371/journal.pone.0011006.

Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

June 2010

Volume

5

Issue

6

Start / End Page

e11006

Related Subject Headings

  • Sequence Homology, Amino Acid
  • Polymerase Chain Reaction
  • Phylogeny
  • Neoplasms
  • Molecular Sequence Data
  • Humans
  • Genetic Predisposition to Disease
  • Genes, BRCA2
  • General Science & Technology
  • Drosophila