Multiple imputation for missing data via sequential regression trees.
Journal Article (Journal Article)
Multiple imputation is particularly well suited to deal with missing data in large epidemiologic studies, because typically these studies support a wide range of analyses by many data users. Some of these analyses may involve complex modeling, including interactions and nonlinear relations. Identifying such relations and encoding them in imputation models, for example, in the conditional regressions for multiple imputation via chained equations, can be daunting tasks with large numbers of categorical and continuous variables. The authors present a nonparametric approach for implementing multiple imputation via chained equations by using sequential regression trees as the conditional models. This has the potential to capture complex relations with minimal tuning by the data imputer. Using simulations, the authors demonstrate that the method can result in more plausible imputations, and hence more reliable inferences, in complex settings than the naive application of standard sequential regression imputation techniques. They apply the approach to impute missing values in data on adverse birth outcomes with more than 100 clinical and survey variables. They evaluate the imputations using posterior predictive checks with several epidemiologic analyses of interest.
Full Text
Duke Authors
Cited Authors
- Burgette, LF; Reiter, JP
Published Date
- November 2010
Published In
Volume / Issue
- 172 / 9
Start / End Page
- 1070 - 1076
PubMed ID
- 20841346
Electronic International Standard Serial Number (EISSN)
- 1476-6256
International Standard Serial Number (ISSN)
- 0002-9262
Digital Object Identifier (DOI)
- 10.1093/aje/kwq260
Language
- eng