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Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial.

Publication ,  Journal Article
Appel, LJ; Champagne, CM; Harsha, DW; Cooper, LS; Obarzanek, E; Elmer, PJ; Stevens, VJ; Vollmer, WM; Lin, P-H; Svetkey, LP; Stedman, SW ...
Published in: JAMA
April 23, 2003

CONTEXT: Weight loss, sodium reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce blood pressure (BP). The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations. OBJECTIVE: To determine the effect on BP of 2 multicomponent, behavioral interventions. DESIGN, SETTING, AND PARTICIPANTS: Randomized trial with enrollment at 4 clinical centers (January 2000-June 2001) among 810 adults (mean [SD] age, 50 [8.9] years; 62% women; 34% African American) with above-optimal BP, including stage 1 hypertension (120-159 mm Hg systolic and 80-95 mm Hg diastolic), and who were not taking antihypertensive medications. INTERVENTION: Participants were randomized to one of 3 intervention groups: (1) "established," a behavioral intervention that implemented established recommendations (n = 268); (2) "established plus DASH,"which also implemented the DASH diet (n = 269); and (3) an "advice only" comparison group (n = 273). MAIN OUTCOME MEASURES: Blood pressure measurement and hypertension status at 6 months. RESULTS: Both behavioral interventions significantly reduced weight, improved fitness, and lowered sodium intake. The established plus DASH intervention also increased fruit, vegetable, and dairy intake. Across the groups, gradients in BP and hypertensive status were evident. After subtracting change in advice only, the mean net reduction in systolic BP was 3.7 mm Hg (P<.001) in the established group and 4.3 mm Hg (P<.001) in the established plus DASH group; the systolic BP difference between the established and established plus DASH groups was 0.6 mm Hg (P =.43). Compared with the baseline hypertension prevalence of 38%, the prevalence at 6 months was 26% in the advice only group, 17% in the established group (P =.01 compared with the advice only group), and 12% in the established plus DASH group (P<.001 compared with the advice only group; P =.12 compared with the established group). The prevalence of optimal BP (<120 mm Hg systolic and <80 mm Hg diastolic) was 19% in the advice only group, 30% in the established group (P =.005 compared with the advice only group), and 35% in the established plus DASH group (P<.001 compared with the advice only group; P =.24 compared with the established group). CONCLUSION: Individuals with above-optimal BP, including stage 1 hypertension, can make multiple lifestyle changes that lower BP and reduce their cardiovascular disease risk.

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Published In

JAMA

DOI

ISSN

0098-7484

Publication Date

April 23, 2003

Volume

289

Issue

16

Start / End Page

2083 / 2093

Location

United States

Related Subject Headings

  • Weight Loss
  • Risk Factors
  • Patient Education as Topic
  • Middle Aged
  • Male
  • Life Style
  • Hypertension
  • Humans
  • Health Behavior
  • General & Internal Medicine
 

Citation

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MLA
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Appel, L. J., Champagne, C. M., Harsha, D. W., Cooper, L. S., Obarzanek, E., Elmer, P. J., … Writing Group of the PREMIER Collaborative Research Group, . (2003). Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA, 289(16), 2083–2093. https://doi.org/10.1001/jama.289.16.2083
Appel, Lawrence J., Catherine M. Champagne, David W. Harsha, Lawton S. Cooper, Eva Obarzanek, Patricia J. Elmer, Victor J. Stevens, et al. “Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial.JAMA 289, no. 16 (April 23, 2003): 2083–93. https://doi.org/10.1001/jama.289.16.2083.
Appel LJ, Champagne CM, Harsha DW, Cooper LS, Obarzanek E, Elmer PJ, et al. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA. 2003 Apr 23;289(16):2083–93.
Appel, Lawrence J., et al. “Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial.JAMA, vol. 289, no. 16, Apr. 2003, pp. 2083–93. Pubmed, doi:10.1001/jama.289.16.2083.
Appel LJ, Champagne CM, Harsha DW, Cooper LS, Obarzanek E, Elmer PJ, Stevens VJ, Vollmer WM, Lin P-H, Svetkey LP, Stedman SW, Young DR, Writing Group of the PREMIER Collaborative Research Group. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA. 2003 Apr 23;289(16):2083–2093.
Journal cover image

Published In

JAMA

DOI

ISSN

0098-7484

Publication Date

April 23, 2003

Volume

289

Issue

16

Start / End Page

2083 / 2093

Location

United States

Related Subject Headings

  • Weight Loss
  • Risk Factors
  • Patient Education as Topic
  • Middle Aged
  • Male
  • Life Style
  • Hypertension
  • Humans
  • Health Behavior
  • General & Internal Medicine