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House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.

Publication ,  Journal Article
Meeker, JD; Stapleton, HM
Published in: Environmental health perspectives
March 2010

Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects.We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters.We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression.TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an interquartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), 5% to 1%) decline in free thyroxine and a 17% (95% CI, 432%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 219%) increase in prolactin and a 19% (95% CI, 30% to 5%) decrease in sperm concentration.OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.

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Published In

Environmental health perspectives

DOI

EISSN

1552-9924

ISSN

0091-6765

Publication Date

March 2010

Volume

118

Issue

3

Start / End Page

318 / 323

Related Subject Headings

  • Young Adult
  • Toxicology
  • Sperm Count
  • Semen
  • Phosphites
  • Organophosphorus Compounds
  • Organophosphates
  • Middle Aged
  • Male
  • Humans
 

Citation

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Meeker, J. D., & Stapleton, H. M. (2010). House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environmental Health Perspectives, 118(3), 318–323. https://doi.org/10.1289/ehp.0901332
Meeker, John D., and Heather M. Stapleton. “House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.Environmental Health Perspectives 118, no. 3 (March 2010): 318–23. https://doi.org/10.1289/ehp.0901332.
Meeker JD, Stapleton HM. House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environmental health perspectives. 2010 Mar;118(3):318–23.
Meeker, John D., and Heather M. Stapleton. “House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.Environmental Health Perspectives, vol. 118, no. 3, Mar. 2010, pp. 318–23. Epmc, doi:10.1289/ehp.0901332.
Meeker JD, Stapleton HM. House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environmental health perspectives. 2010 Mar;118(3):318–323.

Published In

Environmental health perspectives

DOI

EISSN

1552-9924

ISSN

0091-6765

Publication Date

March 2010

Volume

118

Issue

3

Start / End Page

318 / 323

Related Subject Headings

  • Young Adult
  • Toxicology
  • Sperm Count
  • Semen
  • Phosphites
  • Organophosphorus Compounds
  • Organophosphates
  • Middle Aged
  • Male
  • Humans