Dietary prenatal choline supplementation alters postnatal hippocampal structure and function.

Journal Article (Journal Article)

Choline, a compound present in many foods, has recently been classified as an essential nutrient for humans. Studies with animal models indicate that the availability of choline during the prenatal period influences neural and cognitive development. Specifically, prenatal choline supplementation has been shown to enhance working memory and hippocampal long-term potentiation (LTP) in adult offspring. However, the cellular mechanisms underlying these effects remain unclear. Here we report that choline supplementation, during a 6-day gestational period, results in greater excitatory responsiveness, reduced slow afterhyperpolarizations (sAHPs), enhanced afterdepolarizing potentials (ADPs), larger somata, and greater basal dendritic arborization among hippocampal CA1 pyramidal cells studied postnatally in juvenile rats (20-25 days of age). These data indicate that dietary supplementation with a single nutrient, choline, during a brief, critical period of prenatal development, alters the structure and function of hippocampal pyramidal cells.

Full Text

Duke Authors

Cited Authors

  • Li, Q; Guo-Ross, S; Lewis, DV; Turner, D; White, AM; Wilson, WA; Swartzwelder, HS

Published Date

  • April 2004

Published In

Volume / Issue

  • 91 / 4

Start / End Page

  • 1545 - 1555

PubMed ID

  • 14645379

International Standard Serial Number (ISSN)

  • 0022-3077

Digital Object Identifier (DOI)

  • 10.1152/jn.00785.2003


  • eng

Conference Location

  • United States