Tremor varies as a function of the temporal regularity of deep brain stimulation.

Journal Article (Clinical Trial;Journal Article)

The frequency of stimulation is one of the primary factors determining the effectiveness of deep brain stimulation (DBS) in relieving tremor. DBS efficacy, however, may depend not only on the average frequency of stimulation, but also on the temporal pattern of stimulation. We conducted intraoperative measurements of the effect of temporally irregular DBS (nonconstant interpulse intervals) on tremor. As the coefficient of variation of irregular high frequency DBS trains increased, they became less effective at reducing tremor (mixed effects regression model, P<0.04). These data provide evidence that the effects of DBS are dependent not only on the average frequency of DBS, but also on the regularity of the temporal spacing of DBS pulses.

Full Text

Duke Authors

Cited Authors

  • Birdno, MJ; Kuncel, AM; Dorval, AD; Turner, DA; Grill, WM

Published Date

  • March 26, 2008

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 599 - 602

PubMed ID

  • 18388746

Pubmed Central ID

  • PMC2586391

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/WNR.0b013e3282f9e45e


  • eng

Conference Location

  • England