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Molecular genetics of AMD and current animal models.

Publication ,  Journal Article
Edwards, AO; Malek, G
Published in: Angiogenesis
2007

During the past few years systematic investigation into the epidemiology, genetics, and pathophysiology of age-related macular degeneration (AMD) has provided important new insight into this leading cause of vision loss in older persons. These studies provide a view of AMD as a complex trait influenced by well-established genetic and environmental risks that leads to the deposition of inflammatory deposits in the outer retina. This maculopathy leads to visual dysfunction through a variety of mechanisms and complications that can be observed in both humans and animal models. In this review, the risks associated with AMD in humans and the animal models used to study AMD and its complications will be summarized. No effort has been made to perform a comprehensive citation of all areas of AMD genetics and animal models, but rather a selection of observations and supporting references illustrative of the current state of the field is presented.

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Published In

Angiogenesis

DOI

ISSN

0969-6970

Publication Date

2007

Volume

10

Issue

2

Start / End Page

119 / 132

Location

Germany

Related Subject Headings

  • Rats
  • Oncology & Carcinogenesis
  • Mice
  • Macular Degeneration
  • Linkage Disequilibrium
  • Humans
  • Genetic Variation
  • Disease Models, Animal
  • Complement Factor B
  • Chromosomes, Human, Pair 10
 

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Edwards, A. O., & Malek, G. (2007). Molecular genetics of AMD and current animal models. Angiogenesis, 10(2), 119–132. https://doi.org/10.1007/s10456-007-9064-2
Edwards, Albert O., and Goldis Malek. “Molecular genetics of AMD and current animal models.Angiogenesis 10, no. 2 (2007): 119–32. https://doi.org/10.1007/s10456-007-9064-2.
Edwards AO, Malek G. Molecular genetics of AMD and current animal models. Angiogenesis. 2007;10(2):119–32.
Edwards, Albert O., and Goldis Malek. “Molecular genetics of AMD and current animal models.Angiogenesis, vol. 10, no. 2, 2007, pp. 119–32. Pubmed, doi:10.1007/s10456-007-9064-2.
Edwards AO, Malek G. Molecular genetics of AMD and current animal models. Angiogenesis. 2007;10(2):119–132.
Journal cover image

Published In

Angiogenesis

DOI

ISSN

0969-6970

Publication Date

2007

Volume

10

Issue

2

Start / End Page

119 / 132

Location

Germany

Related Subject Headings

  • Rats
  • Oncology & Carcinogenesis
  • Mice
  • Macular Degeneration
  • Linkage Disequilibrium
  • Humans
  • Genetic Variation
  • Disease Models, Animal
  • Complement Factor B
  • Chromosomes, Human, Pair 10