Clinical aspects of MuSK antibody positive seronegative MG.

Journal Article (Journal Article)

Serum antibodies to muscle-specific receptor tyrosine kinase were detected in 12 of 32 patients with generalized seronegative MG. All were women, with onset between ages 21 and 59 years. Seven had prominent neck, shoulder, or respiratory muscle weakness and little or delayed ocular muscle involvement. The response to cholinesterase inhibitors was variable, and electromyographic findings suggested myopathy in several. None improved after thymectomy. All patients improved after plasma exchange, and most had a good response to selected immunotherapy. MuSK antibody status should help diagnose MG with atypical presentations and ensure appropriate patient treatment.

Full Text

Duke Authors

Cited Authors

  • Sanders, DB; El-Salem, K; Massey, JM; McConville, J; Vincent, A

Published Date

  • June 24, 2003

Published In

Volume / Issue

  • 60 / 12

Start / End Page

  • 1978 - 1980

PubMed ID

  • 12821744

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

Digital Object Identifier (DOI)

  • 10.1212/01.wnl.0000065882.63904.53


  • eng

Conference Location

  • United States