The MG-QOL15 for following the health-related quality of life of patients with myasthenia gravis.

Journal Article (Journal Article;Multicenter Study)

The MG-QOL15 is helpful in informing the clinician about the patient's perception of the extent of and dissatisfaction with myasthenia gravis (MG)-related dysfunction. The aims of this study were to determine the usefulness of the MG-QOL15 for following individuals with MG and to guide clinical researchers who plan to use the MG-QOL15. We assessed sensitivity and specificity for detecting clinical change and evaluated test-retest reliability. Sensitivities and specificities of various cut-points of change in scores are presented. Also presented are means and standard deviations of MG-QOL15 scores for all patients and for subgroups of patients. The test-retest reliability coefficient was 98.6%. The MG-QOL15 has an acceptable longitudinal construct validity. We consider this instrument to be most useful for informing the clinician about the patient's perception and tolerance of MG-related dysfunction. More objective measures, such as the MG Composite, should also be used to follow disease severity.

Full Text

Duke Authors

Cited Authors

  • Burns, TM; Grouse, CK; Wolfe, GI; Conaway, MR; Sanders, DB; MG Composite and MG-OL15 Study Group,

Published Date

  • January 2011

Published In

Volume / Issue

  • 43 / 1

Start / End Page

  • 14 - 18

PubMed ID

  • 21082698

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.21883


  • eng

Conference Location

  • United States