Simulation of myopathic motor unit action potentials.

Journal Article (Journal Article)

Normal motor units (MUs) were simulated and their architecture altered to simulate the changes produced by myopathy. The concentric needle electromyographic recordings of motor unit action potentials (MUAPs) from the MUs were then also simulated. These simulated MUAPs showed features that are seen in myopathy: normal amplitude and slightly reduced area, MUAPs with simple waveform and reduced duration, and complex MUAPs with normal or increased duration. The MUAP waveforms were complex because of increased variability of fiber diameter and not because of loss of muscle fibers. The MUAP duration increased when the variability of fiber diameter increased. Finally, MUAPs similar to those seen in neurogenic diseases were produced from MUs in which the only abnormality was increased variability of fiber diameter.

Full Text

Duke Authors

Cited Authors

  • Nandedkar, SD; Sanders, DB

Published Date

  • March 1989

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 197 - 202

PubMed ID

  • 2725550

International Standard Serial Number (ISSN)

  • 0148-639X

Digital Object Identifier (DOI)

  • 10.1002/mus.880120306


  • eng

Conference Location

  • United States