Clinical impact of single-fiber electromyography.

Journal Article (Journal Article;Review)

The major clinical impact of single-fiber electromyography has been from its role in confirming, or excluding, the diagnosis of myasthenia gravis (MG). Jitter measurements also have a clinical role in demonstrating changes in disease severity in patients with MG and Lambert-Eaton myasthenic syndrome, in demonstrating subtle changes in motor unit architecture and physiology in patients with nerve and muscle diseases, and in demonstrating the remote effects of locally injected botulinum toxin. In addition to these clinical roles, the ability to identify the activity from single muscle fibers makes it possible to mark the discharges of single motor units. This, along with information gained by jitter and fiber-density measurements, has uniquely increased our understanding of motor unit organization and function in normal and disease states.

Full Text

Duke Authors

Cited Authors

  • Sanders, DB

Published Date

  • 2002

Published In

  • Muscle Nerve Suppl

Volume / Issue

  • 11 /

Start / End Page

  • S15 - S20

PubMed ID

  • 12116281

Pubmed Central ID

  • 12116281

Digital Object Identifier (DOI)

  • 10.1002/mus.10141


  • eng

Conference Location

  • United States