Skip to main content
Journal cover image

Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis.

Publication ,  Journal Article
Wolfe, GI; Barohn, RJ; Sanders, DB; McDermott, MP
Published in: Muscle Nerve
November 2008

We determined the strength of correlation among, and responsiveness of, outcome measures used in a multicenter, double-blind, placebo-controlled trial of mycophenolate mofetil in combination with prednisone in myasthenia gravis (MG). The primary efficacy measure was the change from baseline in the Quantitative MG (QMG) score at week 12. Secondary outcome measures included the MG-Activities of Daily Living profile (MG-ADL) and MG Manual Muscle Test (MMT). The measures were collected at baseline and at weeks 4, 8, and 12 in the blinded study and at weeks 16, 20, 28, and 36 in an optional open-label extension. At baseline, the QMG was moderately correlated with the MG-ADL (r=0.55, P<0.0001) and the MMT (r=0.53, P<0.0001), but the correlation between the MG-ADL and the MMT was lower (r=0.30, P=0.007). These findings were similar at weeks 4, 8, and 12. Similar correlations were found among the changes in scores from baseline at weeks 12 and 36. The MMT and MG-ADL appeared to be the most sensitive measures for changes in MG status at weeks 12 and 36. Although a task force has recommended use of the QMG in prospective MG trials, the MMT and MG-ADL appear to be suitable alternatives and offer potential advantages. No special training or equipment is required, and they take less time.

Duke Scholars

Published In

Muscle Nerve

DOI

ISSN

0148-639X

Publication Date

November 2008

Volume

38

Issue

5

Start / End Page

1429 / 1433

Location

United States

Related Subject Headings

  • Time Factors
  • Seveso Accidental Release
  • Retrospective Studies
  • Psychomotor Performance
  • Outcome Assessment, Health Care
  • Neurology & Neurosurgery
  • Mycophenolic Acid
  • Myasthenia Gravis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wolfe, G. I., Barohn, R. J., Sanders, D. B., & McDermott, M. P. (2008). Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis. Muscle Nerve, 38(5), 1429–1433. https://doi.org/10.1002/mus.21142
Wolfe, Gil I., Richard J. Barohn, Donald B. Sanders, and Michel P. McDermott. “Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis.Muscle Nerve 38, no. 5 (November 2008): 1429–33. https://doi.org/10.1002/mus.21142.
Wolfe GI, Barohn RJ, Sanders DB, McDermott MP. Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis. Muscle Nerve. 2008 Nov;38(5):1429–33.
Wolfe, Gil I., et al. “Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis.Muscle Nerve, vol. 38, no. 5, Nov. 2008, pp. 1429–33. Pubmed, doi:10.1002/mus.21142.
Wolfe GI, Barohn RJ, Sanders DB, McDermott MP. Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis. Muscle Nerve. 2008 Nov;38(5):1429–1433.
Journal cover image

Published In

Muscle Nerve

DOI

ISSN

0148-639X

Publication Date

November 2008

Volume

38

Issue

5

Start / End Page

1429 / 1433

Location

United States

Related Subject Headings

  • Time Factors
  • Seveso Accidental Release
  • Retrospective Studies
  • Psychomotor Performance
  • Outcome Assessment, Health Care
  • Neurology & Neurosurgery
  • Mycophenolic Acid
  • Myasthenia Gravis
  • Middle Aged
  • Male