Mycophenolate mofetil in myasthenia gravis: the unanswered question.

Journal Article (Journal Article)

Myasthenia gravis (MG) is an autoimmune disease that leads to muscular weakness, which can significantly affect the patient's daily functions. If left untreated, the mortality rate can be as high as 30%. Effective immunosuppression is the cornerstone of treatment of MG, although most currently available immunomodulatory drugs are associated with unacceptable side effects, delayed onset of therapeutic action, or both. Mycophenolate mofetil (MMF) might be better tolerated than other immunosuppressants and many case reports and uncontrolled trials have indicated that it is effective in MG. However, two recently concluded clinical trials failed to demonstrate the efficacy of MMF in MG. This paper critically reviews the existing evidence on the efficacy of MMF in MG and provides the authors' view of its role in current practice.

Full Text

Duke Authors

Cited Authors

  • Phan, C; Sanders, DB; Siddiqi, ZA

Published Date

  • October 2008

Published In

Volume / Issue

  • 9 / 14

Start / End Page

  • 2545 - 2551

PubMed ID

  • 18778192

Electronic International Standard Serial Number (EISSN)

  • 1744-7666

Digital Object Identifier (DOI)

  • 10.1517/14656566.9.14.2545


  • eng

Conference Location

  • England