Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.

Published

Journal Article (Review)

Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction in which patients experience fluctuating skeletal muscle weakness that often affects selected muscle groups preferentially. The target of the autoimmune attack in most cases is the skeletal muscle acetylcholine receptor (AChR), but in others, non-AChR components of the neuromuscular junction, such as the muscle-specific receptor tyrosine kinase, are targeted. The pathophysiological result is muscle endplate dysfunction and consequent fatigable muscle weakness. Clinical presentations vary substantially, both for anti-AChR positive and negative MG, and accurate diagnosis and selection of effective treatment depends on recognition of less typical as well as classic disease phenotypes. Accumulating evidence suggests that clinical MG subgroups might respond differently to treatment. In this Review, we provide current information about the epidemiology, immunopathogenesis, clinical presentations, diagnosis, and treatment of MG, including emerging therapeutic strategies.

Full Text

Duke Authors

Cited Authors

  • Meriggioli, MN; Sanders, DB

Published Date

  • May 2009

Published In

Volume / Issue

  • 8 / 5

Start / End Page

  • 475 - 490

PubMed ID

  • 19375665

Pubmed Central ID

  • 19375665

International Standard Serial Number (ISSN)

  • 1474-4422

Digital Object Identifier (DOI)

  • 10.1016/S1474-4422(09)70063-8

Language

  • eng

Conference Location

  • England