Stress response of the trabecular meshwork.

Journal Article (Journal Article;Review)

The trabecular meshwork (TM) is known to be subjected to different types of stress such as mechanical, oxidative, and phagocytic stress. Although short-term exposure to these stresses is expected to elicit adaptive responses, long-term exposure may lead to permanent alterations in the tissue physiology and contribute to the pathologic increase in aqueous humor outflow resistance frequently associated with glaucoma. A fuller understanding of the cell-specific and tissue-specific responses to stress in the TM, including changes in gene and protein expression, signal transduction, and potential pathogenic effects, could lead to novel prevention and therapeutic strategies for glaucoma. This review summarizes the current information available about how the TM responds to mechanical, oxidative, and phagocytic stress, as well as the evidence supporting the role that such responses may have in the alterations of the TM in aging and glaucoma.

Full Text

Duke Authors

Cited Authors

  • Liton, PB; Gonzalez, P

Published Date

  • August 2008

Published In

Volume / Issue

  • 17 / 5

Start / End Page

  • 378 - 385

PubMed ID

  • 18703948

Pubmed Central ID

  • PMC3140831

Electronic International Standard Serial Number (EISSN)

  • 1536-481X

Digital Object Identifier (DOI)

  • 10.1097/IJG.0b013e31815f52a8


  • eng

Conference Location

  • United States