Natural food folate and late-life depression.

Journal Article (Journal Article)

Low folate status has been linked to depression, but findings have been inconsistent. The authors sought to examine the association between folate intake and late-life depression. This cross-sectional study included individuals age 60 and older (n = 111 depression, n = 136 comparison). Depression participants received psychiatric care. Folate and kilocalorie intakes were assessed with a Block 1998 food frequency questionnaire. Naturally occurring food folate was inversely associated with depression after controlling for age, sex, race, education, and total energy (P = 0.0047). All other folate variables including total dietary folate and folic acid were non-significant for depression. These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health. Alternatively, natural folate may be a surrogate for other nutrients or overall dietary quality.

Full Text

Duke Authors

Cited Authors

  • Payne, ME; Jamerson, BD; Potocky, CF; Ashley-Koch, AE; Speer, MC; Steffens, DC

Published Date

  • October 2009

Published In

Volume / Issue

  • 28 / 4

Start / End Page

  • 348 - 358

PubMed ID

  • 21184377

Pubmed Central ID

  • PMC3324853

Electronic International Standard Serial Number (EISSN)

  • 1540-8566

Digital Object Identifier (DOI)

  • 10.1080/01639360903417181


  • eng

Conference Location

  • United States