Natural food folate and late-life depression.


Journal Article

Low folate status has been linked to depression, but findings have been inconsistent. The authors sought to examine the association between folate intake and late-life depression. This cross-sectional study included individuals age 60 and older (n = 111 depression, n = 136 comparison). Depression participants received psychiatric care. Folate and kilocalorie intakes were assessed with a Block 1998 food frequency questionnaire. Naturally occurring food folate was inversely associated with depression after controlling for age, sex, race, education, and total energy (P = 0.0047). All other folate variables including total dietary folate and folic acid were non-significant for depression. These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health. Alternatively, natural folate may be a surrogate for other nutrients or overall dietary quality.

Full Text

Duke Authors

Cited Authors

  • Payne, ME; Jamerson, BD; Potocky, CF; Ashley-Koch, AE; Speer, MC; Steffens, DC

Published Date

  • October 2009

Published In

Volume / Issue

  • 28 / 4

Start / End Page

  • 348 - 358

PubMed ID

  • 21184377

Pubmed Central ID

  • 21184377

Electronic International Standard Serial Number (EISSN)

  • 1540-8566

International Standard Serial Number (ISSN)

  • 0163-9366

Digital Object Identifier (DOI)

  • 10.1080/01639360903417181


  • eng