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Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.

Publication ,  Journal Article
Kring, SII; Brummett, BH; Barefoot, J; Garrett, ME; Ashley-Koch, AE; Boyle, SH; Siegler, IC; Sørensen, TIA; Williams, RB
Published in: Psychosom Med
June 2010

OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations. METHODS: The association between rs769450, rs405509, rs439401, and metabolic traits were analyzed in a U.S. sample of 126 white caregivers of a relative with Alzheimer';s disease or other major dementia and 122 white controls. The associations were analyzed, using multivariate analysis of variance adjusted for age, sex, and medications. RESULTS: Significant multivariate interactions were found, using both additive (p = .009) and dominant (p = .047) models between rs439401 (C/T) and caregiver stress in relation to a profile of metabolic variables. Univariate analyses found the TT genotype to be associated with more adverse levels of waist circumference (interaction, p = .026), triglycerides (interaction, p = .001) and high-density lipoprotein cholesterol (interaction, p = .001) among caregivers but with a more favorable profile of these endophenotypes among controls. There were no significant associations or interactions involving the other two single nucleotide polymorphisms. CONCLUSION: The APOE rs439401 TT genotype is associated with an adverse metabolic profile among chronically stressed individuals compared with individuals not similarly stressed in whom a more favorable profile is expressed. Confirmation of these results in further research would indicate that the TT genotype can be used to identify persons at high risk for CVD when subjected to chronic stress.

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Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

June 2010

Volume

72

Issue

5

Start / End Page

427 / 433

Location

United States

Related Subject Headings

  • Waist Circumference
  • Triglycerides
  • Stress, Psychological
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Middle Aged
  • Male
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kring, S. I. I., Brummett, B. H., Barefoot, J., Garrett, M. E., Ashley-Koch, A. E., Boyle, S. H., … Williams, R. B. (2010). Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosom Med, 72(5), 427–433. https://doi.org/10.1097/PSY.0b013e3181de30ad
Kring, Sofia I Iqbal, Beverly H. Brummett, John Barefoot, Melanie E. Garrett, Allison E. Ashley-Koch, Stephen H. Boyle, Ilene C. Siegler, Thorkild I. A. Sørensen, and Redford B. Williams. “Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.Psychosom Med 72, no. 5 (June 2010): 427–33. https://doi.org/10.1097/PSY.0b013e3181de30ad.
Kring SII, Brummett BH, Barefoot J, Garrett ME, Ashley-Koch AE, Boyle SH, et al. Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosom Med. 2010 Jun;72(5):427–33.
Kring, Sofia I. Iqbal, et al. “Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.Psychosom Med, vol. 72, no. 5, June 2010, pp. 427–33. Pubmed, doi:10.1097/PSY.0b013e3181de30ad.
Kring SII, Brummett BH, Barefoot J, Garrett ME, Ashley-Koch AE, Boyle SH, Siegler IC, Sørensen TIA, Williams RB. Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosom Med. 2010 Jun;72(5):427–433.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

June 2010

Volume

72

Issue

5

Start / End Page

427 / 433

Location

United States

Related Subject Headings

  • Waist Circumference
  • Triglycerides
  • Stress, Psychological
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Middle Aged
  • Male
  • Humans
  • Genotype