Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.

Journal Article

This study was designed to investigate whether small ubiquitin-like modifier (SUMO) conjugation is activated after focal cerebral ischemia. Transient ischemia induced a dramatic increase in SUMO2/3 protein conjugates. The most pronounced changes were found in the parietal cortex. SUMO2/3 conjugation was particularly high in neurons located at the border of the middle cerebral artery territory where sumoylated proteins translocated to the nucleus. Considering the marked effect of SUMO conjugation on the function of target proteins, it is very likely that the postischemic activation of sumoylation has a significant effect on the fate of neurons exposed to transient ischemia.

Full Text

Duke Authors

Cited Authors

  • Yang, W; Sheng, H; Warner, DS; Paschen, W

Published Date

  • May 2008

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 892 - 896

PubMed ID

  • 18167501

International Standard Serial Number (ISSN)

  • 0271-678X

Digital Object Identifier (DOI)

  • 10.1038/sj.jcbfm.9600601

Language

  • eng

Conference Location

  • United States