How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?

Journal Article (Journal Article)

Extracranial stereotactic radiosurgery (ESR) is now undergoing clinical investigation at numerous institutions as a treatment for solitary malignant lesions. Because there is no standard ESR technique, the same minimum dose might be applied through widely variable target dose-volume histograms. For multicenter trials of ESR or interinstitutional comparisons, a reliable index of radiobiological dose equivalency might facilitate the evaluation of dose-response relationships. Equivalent uniform dose (EUD) and tumor control probability (TCP) were considered for this application. While EUD appears more robust for the prospective description of ESR, TCP is expected to remain more valuable for a post hoc estimation of radiosensitivity parameters.

Full Text

Duke Authors

Cited Authors

  • Kavanagh, BD; Timmerman, RD; Benedict, SH; Wu, Q; Schefter, TE; Stuhr, K; McCourt, S; Newman, F; Cardinale, RM; Gaspar, LF

Published Date

  • March 2003

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 321 - 324

PubMed ID

  • 12674231

International Standard Serial Number (ISSN)

  • 0094-2405

Digital Object Identifier (DOI)

  • 10.1118/1.1543571


  • eng

Conference Location

  • United States