Alcohol use and clinical manifestations of tuberculosis.

Journal Article (Journal Article)

OBJECTIVES: Excess alcohol use represents a significant challenge in tuberculosis control. Whether alcohol use enhances transmission of Mycobacterium tuberculosis is not known. METHODS: We analyzed North Carolina, USA surveillance data for all adult (> 14 years) tuberculosis cases reported 1994-2006 (N = 5556). RESULTS: The prevalence of excess alcohol use among tuberculosis cases declined from 27.3% in 1994 to 17.9% in 2006. Cases with excess alcohol use were more likely to have pulmonary tuberculosis compared with cases without excess alcohol use (92.5% vs. 77.2%, p < 0.0001). Among pulmonary cases, excess alcohol use was associated with cavities on chest radiograph (36.8% vs. 28.2%, p < 0.0001) and positive acid-fast sputum smears (65.9% vs. 45.8%, p < 0.0001). CONCLUSIONS: Although excess alcohol use is becoming less prevalent among tuberculosis cases in North Carolina, cases who use excess alcohol had clinical features associated with greater infectiousness, and represent a significant public health problem.

Full Text

Duke Authors

Cited Authors

  • Fiske, CT; Hamilton, CD; Stout, JE

Published Date

  • November 2008

Published In

Volume / Issue

  • 57 / 5

Start / End Page

  • 385 - 391

PubMed ID

  • 18848357

Pubmed Central ID

  • PMC2637396

Electronic International Standard Serial Number (EISSN)

  • 1532-2742

Digital Object Identifier (DOI)

  • 10.1016/j.jinf.2008.08.011


  • eng

Conference Location

  • England