Skip to main content
Journal cover image

Detection of proximal colorectal cancers through analysis of faecal DNA.

Publication ,  Journal Article
Traverso, G; Shuber, A; Olsson, L; Levin, B; Johnson, C; Hamilton, SR; Boynton, K; Kinzler, KW; Vogelstein, B
Published in: Lancet (London, England)
February 2002

Detection of mutations in faecal DNA represents a promising, non-invasive approach for detecting colorectal cancers in average-risk populations. One of the first practical applications of this technology involves the examination of microsatellite markers in sporadic cancers with mismatch-repair deficiencies. Since such cancers nearly always occur in the proximal colon, this test might be useful as an adjunct to sigmoidoscopy, which detects only distal colorectal lesions. We report here the first in-depth analysis of faecal DNA from patients with proximal cancers to determine the feasibility, sensitivity, and specificity of this approach. Using a sensitive method for microsatellite mutation detection, we found that 18 of 46 cancers had microsatellite alterations and that identical mutations could be identified in the faecal DNA of 17 of these 18 cases.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lancet (London, England)

DOI

EISSN

1474-547X

ISSN

0140-6736

Publication Date

February 2002

Volume

359

Issue

9304

Start / End Page

403 / 404

Related Subject Headings

  • Sensitivity and Specificity
  • Microsatellite Repeats
  • Humans
  • General & Internal Medicine
  • Feces
  • Feasibility Studies
  • DNA
  • Colorectal Neoplasms
  • Colonoscopy
  • Adenoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Traverso, G., Shuber, A., Olsson, L., Levin, B., Johnson, C., Hamilton, S. R., … Vogelstein, B. (2002). Detection of proximal colorectal cancers through analysis of faecal DNA. Lancet (London, England), 359(9304), 403–404. https://doi.org/10.1016/s0140-6736(02)07591-8
Traverso, Giovanni, Anthony Shuber, Louise Olsson, Bernard Levin, Constance Johnson, Stanley R. Hamilton, Kevin Boynton, Kenneth W. Kinzler, and Bert Vogelstein. “Detection of proximal colorectal cancers through analysis of faecal DNA.Lancet (London, England) 359, no. 9304 (February 2002): 403–4. https://doi.org/10.1016/s0140-6736(02)07591-8.
Traverso G, Shuber A, Olsson L, Levin B, Johnson C, Hamilton SR, et al. Detection of proximal colorectal cancers through analysis of faecal DNA. Lancet (London, England). 2002 Feb;359(9304):403–4.
Traverso, Giovanni, et al. “Detection of proximal colorectal cancers through analysis of faecal DNA.Lancet (London, England), vol. 359, no. 9304, Feb. 2002, pp. 403–04. Epmc, doi:10.1016/s0140-6736(02)07591-8.
Traverso G, Shuber A, Olsson L, Levin B, Johnson C, Hamilton SR, Boynton K, Kinzler KW, Vogelstein B. Detection of proximal colorectal cancers through analysis of faecal DNA. Lancet (London, England). 2002 Feb;359(9304):403–404.
Journal cover image

Published In

Lancet (London, England)

DOI

EISSN

1474-547X

ISSN

0140-6736

Publication Date

February 2002

Volume

359

Issue

9304

Start / End Page

403 / 404

Related Subject Headings

  • Sensitivity and Specificity
  • Microsatellite Repeats
  • Humans
  • General & Internal Medicine
  • Feces
  • Feasibility Studies
  • DNA
  • Colorectal Neoplasms
  • Colonoscopy
  • Adenoma