Molecular approaches for colorectal cancer screening.

Published

Journal Article (Review)

Molecular genetic approaches for colorectal cancer screening using stool samples have the potential to be very specific, sensitive and cost effective. K-ras oncogene mutation, observed in about 50% of the colorectal tumours, serves as an ideal target for such an approach. Several studies have shown that K-ras gene mutations present in the tumours can be detected from the stool of patients with colorectal cancer. The challenge for clinical application, however, is to develop a simple method for robust PCR amplification and a reliable assay for K-ras gene mutation detection in the stool samples.

Full Text

Duke Authors

Cited Authors

  • Jen, J; Johnson, C; Levin, B

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 213 - 217

PubMed ID

  • 9585023

Pubmed Central ID

  • 9585023

Electronic International Standard Serial Number (EISSN)

  • 1473-5687

International Standard Serial Number (ISSN)

  • 0954-691X

Language

  • eng