Molecular approaches for colorectal cancer screening.

Journal Article (Review;Journal Article)

Molecular genetic approaches for colorectal cancer screening using stool samples have the potential to be very specific, sensitive and cost effective. K-ras oncogene mutation, observed in about 50% of the colorectal tumours, serves as an ideal target for such an approach. Several studies have shown that K-ras gene mutations present in the tumours can be detected from the stool of patients with colorectal cancer. The challenge for clinical application, however, is to develop a simple method for robust PCR amplification and a reliable assay for K-ras gene mutation detection in the stool samples.

Full Text

Duke Authors

Cited Authors

  • Jen, J; Johnson, C; Levin, B

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 213 - 217

PubMed ID

  • 9585023

Electronic International Standard Serial Number (EISSN)

  • 1473-5687

International Standard Serial Number (ISSN)

  • 0954-691X

Digital Object Identifier (DOI)

  • 10.1097/00042737-199803000-00004

Language

  • eng