CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy.
Publication
, Journal Article
Murad, YM; Clay, TM; Lyerly, HK; Morse, MA
Published in: Expert Opin Biol Ther
August 2007
Stimulation of toll-like receptor (TLR)9 activates human plasmacytoid dendritic cells and B cells, and induces potent innate immune responses in preclinical tumor models and in patients. CpG oligodeoxynucleotides (ODNs) are TLR9 agonists that show promising results as vaccine adjuvants and in the treatment of cancers, infections, asthma and allergy. PF-3512676 (ProMune) was developed as a TLR9 agonist for the treatment of cancer as monotherapy and as an adjuvant in combination with chemo- and immunotherapy. Phase I and II trials have tested this drug in several hematopoietic and solid tumors. Pfizer has initiated Phase III trials to test PF-3512676 in combination with standard chemotherapy for non-small-cell lung cancer.
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Published In
Expert Opin Biol Ther
DOI
EISSN
1744-7682
Publication Date
August 2007
Volume
7
Issue
8
Start / End Page
1257 / 1266
Location
England
Related Subject Headings
- Toll-Like Receptor 9
- Randomized Controlled Trials as Topic
- Oligodeoxyribonucleotides
- Neoplasms
- Immunology
- Humans
- Antineoplastic Agents
- Animals
- Adjuvants, Immunologic
- 3206 Medical biotechnology
Citation
APA
Chicago
ICMJE
MLA
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Murad, Y. M., Clay, T. M., Lyerly, H. K., & Morse, M. A. (2007). CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy. Expert Opin Biol Ther, 7(8), 1257–1266. https://doi.org/10.1517/14712598.7.8.1257
Murad, Yanal M., Timothy M. Clay, H Kim Lyerly, and Michael A. Morse. “CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy.” Expert Opin Biol Ther 7, no. 8 (August 2007): 1257–66. https://doi.org/10.1517/14712598.7.8.1257.
Murad YM, Clay TM, Lyerly HK, Morse MA. CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy. Expert Opin Biol Ther. 2007 Aug;7(8):1257–66.
Murad, Yanal M., et al. “CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy.” Expert Opin Biol Ther, vol. 7, no. 8, Aug. 2007, pp. 1257–66. Pubmed, doi:10.1517/14712598.7.8.1257.
Murad YM, Clay TM, Lyerly HK, Morse MA. CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy. Expert Opin Biol Ther. 2007 Aug;7(8):1257–1266.
Published In
Expert Opin Biol Ther
DOI
EISSN
1744-7682
Publication Date
August 2007
Volume
7
Issue
8
Start / End Page
1257 / 1266
Location
England
Related Subject Headings
- Toll-Like Receptor 9
- Randomized Controlled Trials as Topic
- Oligodeoxyribonucleotides
- Neoplasms
- Immunology
- Humans
- Antineoplastic Agents
- Animals
- Adjuvants, Immunologic
- 3206 Medical biotechnology