Dendritic cell-based immunotherapy.

Published

Journal Article (Review)

Dendritic cells (DCs) play a crucial role in the induction of antigen-specific T-cell responses, and therefore their use for the active immunotherapy of malignancies has been studied with considerable interest. More than a decade has passed since the publication of the first clinical data of DC-based vaccines, and through this and subsequent studies, a number of important developmental insights have been gleaned. These include the ideal source and type of DCs, the discovery of novel antigens and methods of loading DCs, the role of DC maturation, and the most efficient route of immunization. The generation of immune responses against tumor antigens after DC immunization has been demonstrated, and favorable clinical responses have been reported in some patients; however, it is difficult to pool the results as a whole, and thus the body of data remains inconclusive, in part because of varying DC preparation and vaccination protocols, the use of different forms of antigens, and, most importantly, a lack of rigorous criteria for defining clinical responses. As such, the standardization of clinical and immunologic criteria utilized, as well as DC preparations employed, will allow for the comparison of results across multiple clinical studies and is required in order for future trials to measure the true value and role of this treatment modality. In addition, issues regarding the optimal dose and clinical setting for the application of DC vaccines remain to be resolved, and recent clinical studies have been designed to begin to address these questions.

Full Text

Duke Authors

Cited Authors

  • Osada, T; Clay, TM; Woo, CY; Morse, MA; Lyerly, HK

Published Date

  • September 2006

Published In

Volume / Issue

  • 25 / 5-6

Start / End Page

  • 377 - 413

PubMed ID

  • 17169781

Pubmed Central ID

  • 17169781

Electronic International Standard Serial Number (EISSN)

  • 1563-5244

International Standard Serial Number (ISSN)

  • 0883-0185

Digital Object Identifier (DOI)

  • 10.1080/08830180600992456

Language

  • eng