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Virus-based therapies for colon cancer.

Publication ,  Journal Article
Morse, MA
Published in: Expert Opin Biol Ther
December 2005

Viral vectors are under development for anticancer therapy. As they can infect tumours and activate the immune system, viral vectors may directly destroy cancers (oncolysis), deliver genes with antitumour activity directly to the cancer cells, or act as cancer vaccines. Better insights into the biology of the various vectors in use (e.g., poxvectors, adenovirus, adeno-associated virus, reovirus, Newcastle disease virus) are making it possible to engineer viruses that are more tumour-specific, efficient at tumour infection, and which have enhanced safety due to incorporation of safeguards should dissemination occur. As considerable research has focused on therapy of colon cancer with viral vectors, this review will illustrate the major concepts of viral therapy of cancers with examples from studies targeting colorectal carcinoma.

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Published In

Expert Opin Biol Ther

DOI

EISSN

1744-7682

Publication Date

December 2005

Volume

5

Issue

12

Start / End Page

1627 / 1633

Location

England

Related Subject Headings

  • Oncolytic Virotherapy
  • Immunology
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • Colonic Neoplasms
  • Cancer Vaccines
  • Antineoplastic Agents
  • Animals
  • 3206 Medical biotechnology
 

Citation

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Morse, M. A. (2005). Virus-based therapies for colon cancer. Expert Opin Biol Ther, 5(12), 1627–1633. https://doi.org/10.1517/14712598.5.12.1627
Morse, Michael A. “Virus-based therapies for colon cancer.Expert Opin Biol Ther 5, no. 12 (December 2005): 1627–33. https://doi.org/10.1517/14712598.5.12.1627.
Morse MA. Virus-based therapies for colon cancer. Expert Opin Biol Ther. 2005 Dec;5(12):1627–33.
Morse, Michael A. “Virus-based therapies for colon cancer.Expert Opin Biol Ther, vol. 5, no. 12, Dec. 2005, pp. 1627–33. Pubmed, doi:10.1517/14712598.5.12.1627.
Morse MA. Virus-based therapies for colon cancer. Expert Opin Biol Ther. 2005 Dec;5(12):1627–1633.

Published In

Expert Opin Biol Ther

DOI

EISSN

1744-7682

Publication Date

December 2005

Volume

5

Issue

12

Start / End Page

1627 / 1633

Location

England

Related Subject Headings

  • Oncolytic Virotherapy
  • Immunology
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • Colonic Neoplasms
  • Cancer Vaccines
  • Antineoplastic Agents
  • Animals
  • 3206 Medical biotechnology