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Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model.

Publication ,  Journal Article
Mallery, SR; Shenderova, A; Pei, P; Begum, S; Ciminieri, JR; Wilson, RF; Casto, BC; Schuller, DE; Morse, MA
Published in: Anticancer Res
2001

This study investigated whether local delivery of 10-hydroxycamptothecin provides effective inductive chemotherapy as assessed by significant tumor reduction. Established tumorigenic human oral squamous cell carcinoma cells were used for these experiments. The experimental groups were comprised of: control (blank (no drug) poly(lactide-co-glycolide) (PLGA) microspheres), intraperitoneal 10-hydroxycamptothecin delivery + blank microspheres, local bolus 10-hydroxycamptothecin + blank microspheres, and PLGA controlled-release microspheres. The 10-hydroxycamptothecin dose administered was 12 mg/kg (bolus-intraperitoneal, local) or controlled-release over 10 days. Regardless of delivery route, 10-hydroxycamptothecin significantly reduces tumor volume. However, PLGA microspheres provide significantly higher intratumor-drug concentrations (approximately 10 and 100 fold higher) relative to local bolus and intraperitoneal routes, respectively. Also, only the PLGA microspheres significantly reduced tumor weights. Camptothecin clinical applications are limited by drug inactivation at physiological pH and the need for sustained infusions. However, due to their acidic, camptothecin-stabilizing microclimate, PLGA microspheres could provide a novel delivery system for camptothecin-based induction chemotherapy.

Duke Scholars

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

2001

Volume

21

Issue

3B

Start / End Page

1713 / 1722

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Time Factors
  • Polymers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Polyglactin 910
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Neoplasm Metastasis
  • Mouth Neoplasms
 

Citation

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MLA
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Mallery, S. R., Shenderova, A., Pei, P., Begum, S., Ciminieri, J. R., Wilson, R. F., … Morse, M. A. (2001). Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. Anticancer Res, 21(3B), 1713–1722.
Mallery, S. R., A. Shenderova, P. Pei, S. Begum, J. R. Ciminieri, R. F. Wilson, B. C. Casto, D. E. Schuller, and M. A. Morse. “Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model.Anticancer Res 21, no. 3B (2001): 1713–22.
Mallery SR, Shenderova A, Pei P, Begum S, Ciminieri JR, Wilson RF, Casto BC, Schuller DE, Morse MA. Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. Anticancer Res. 2001;21(3B):1713–1722.

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

2001

Volume

21

Issue

3B

Start / End Page

1713 / 1722

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Time Factors
  • Polymers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Polyglactin 910
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Neoplasm Metastasis
  • Mouth Neoplasms