Depletion of human regulatory T cells.

Journal Article

Regulatory T cells (Treg) have become increasingly relevant in the study of human disease including cancer. Treg cells have been shown to inhibit anti-tumor immune responses, and elevated Treg levels have been associated with certain types of cancer. Similarly, depletion of Tregs by various methods can also enhance anti-tumor immune responses. We have found a prevalence of Treg in cancer patients when compared to normal volunteers. In addition, we have shown that the depletion of Treg using the IL-2 fusion protein denileukin diftitox decreased Treg function and increased antigen-specific T cell response to a cancer vaccine. These results indicate the potential for combining Treg depletion with anti-cancer vaccines to enhance tumor antigen-specific immune responses and the need to explore the dose and schedule of Treg depletion strategies in optimizing vaccine efforts.

Full Text

Duke Authors

Cited Authors

  • Hobeika, AC; Morse, MA; Osada, T; Peplinski, S; Lyerly, HK; Clay, TM

Published Date

  • 2011

Published In

Volume / Issue

  • 707 /

Start / End Page

  • 219 - 231

PubMed ID

  • 21287338

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

Digital Object Identifier (DOI)

  • 10.1007/978-1-61737-979-6_14

Language

  • eng

Conference Location

  • United States