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Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report.

Publication ,  Journal Article
Peters, KB; McLendon, R; Morse, MA; Vredenburgh, JJ
Published in: Case Rep Oncol
April 8, 2010

Hemangiopericytoma (HPC) is a rare sarcomatous tumor arising from pericytes, a support cell found in blood vessels. These tumors can occur throughout the body, particularly in the lower extremities and retroperitoneum. In rare circumstances, HPCs can arise from the meninges. In these cases, they behave similar to meningiomas, in particular angiomatous meningiomas, but tend to be more aggressive and are likely to recur. Treatment usually focuses on surgical resection and radiotherapy with possible inclusion of chemotherapy for control of recurrent disease. We describe a case of recurrent right temporal HPC that first manifested as a paraneoplastic syndrome of oncogenic osteomalacia. Despite maximum therapy, this patient experienced multiple recurrences of the tumor, and immunohistochemical analysis revealed overexpression of platelet-derived growth factor receptor, a member of the SRC-related tyrosine kinases. After multiple recurrences, the patient's tumor has been stable with treatment with monotherapy utilizing molecularly targeted therapy to SRC-related tyrosine kinases. This is the first case report of the treatment of recurrent meningeal HPC with molecularly targeted therapy to SRC-related tyrosine kinases.

Duke Scholars

Published In

Case Rep Oncol

DOI

ISSN

1662-6575

Publication Date

April 8, 2010

Volume

3

Issue

1

Start / End Page

93 / 97

Location

Switzerland

Related Subject Headings

  • 3211 Oncology and carcinogenesis
 

Citation

APA
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ICMJE
MLA
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Peters, K. B., McLendon, R., Morse, M. A., & Vredenburgh, J. J. (2010). Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report. Case Rep Oncol, 3(1), 93–97. https://doi.org/10.1159/000307468
Peters, Katherine B., Roger McLendon, Michael A. Morse, and James J. Vredenburgh. “Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report.Case Rep Oncol 3, no. 1 (April 8, 2010): 93–97. https://doi.org/10.1159/000307468.
Peters KB, McLendon R, Morse MA, Vredenburgh JJ. Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report. Case Rep Oncol. 2010 Apr 8;3(1):93–7.
Peters, Katherine B., et al. “Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report.Case Rep Oncol, vol. 3, no. 1, Apr. 2010, pp. 93–97. Pubmed, doi:10.1159/000307468.
Peters KB, McLendon R, Morse MA, Vredenburgh JJ. Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report. Case Rep Oncol. 2010 Apr 8;3(1):93–97.
Journal cover image

Published In

Case Rep Oncol

DOI

ISSN

1662-6575

Publication Date

April 8, 2010

Volume

3

Issue

1

Start / End Page

93 / 97

Location

Switzerland

Related Subject Headings

  • 3211 Oncology and carcinogenesis