The development of therapeutic and preventive vaccines for gastric cancer and Helicobacter pylori.


Journal Article (Review)

Gastric cancer is one of the most important worldwide public health problems. Convincing epidemiologic and etiologic associations have been made between the development of gastric cancer and infection with Helicobacter pylori. H. pylori not only has adapted to survive within the harsh environment of the stomach but also is able to modulate and avoid endogenous immune responses. The design and creation of efficacious vaccine strategies against H. pylori requires an understanding of the complex interactions that make up mucosal immunity. An effective vaccine strategy against H. pylori has the potential to affect significantly on population health worldwide.

Full Text

Duke Authors

Cited Authors

  • Chui, SY; Clay, TM; Lyerly, HK; Morse, MA

Published Date

  • August 2005

Published In

Volume / Issue

  • 14 / 8

Start / End Page

  • 1883 - 1889

PubMed ID

  • 16103431

Pubmed Central ID

  • 16103431

International Standard Serial Number (ISSN)

  • 1055-9965

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-04-0775


  • eng

Conference Location

  • United States