Investigation of HIFU-induced anti-tumor immunity in a murine tumor model.

High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized treatment of cancers. While current clinical strategies employ HIFU exclusively for thermal ablation of the target sites, biological responses associated with both thermal and mechanical damage from focused ultrasound have not been thoroughly investigated. In particular, endogenous danger signals from HIFU-damaged tumor cells may trigger the activation of dendritic cells. This response may play a critical role in a HIFU-elicited anti-tumor immune response which can be harnessed for more effective treatment.

Full Text

Duke Authors

Cited Authors

  • Hu, Z; Yang, XY; Liu, Y; Sankin, GN; Pua, EC; Morse, MA; Lyerly, HK; Clay, TM; Zhong, P

Published Date

  • 2007

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 34 -

PubMed ID

  • 17625013

Electronic International Standard Serial Number (EISSN)

  • 1479-5876

Digital Object Identifier (DOI)

  • 10.1186/1479-5876-5-34


  • eng

Citation Source

  • PubMed