Single-molecule force spectroscopy of bimolecular reactions: system homology in the mechanical activation of ligand substitution reactions.

Journal Article

The mechanochemistry of the bimolecular nucleophilic substitution of DMSO for substituted pyridines at a square-planar pincer Pd(II) center was investigated using single-molecule force spectroscopy (SMFS). The SMFS data are interpreted in terms of the Bell-Evans model, which gives thermal off-rates for two reactions that agree well with previous, stress-free measurements. The characteristic force dependency of the rupture rate, fbeta, is effectively constant for the two reactions examined (22 +/- 2 and 24 +/- 2 pN), and the system homology in the mechanical response is consistent with expected similarities in the reaction potential energy surfaces.

Full Text

Duke Authors

Cited Authors

  • Kersey, FR; Yount, WC; Craig, SL

Published Date

  • March 2006

Published In

Volume / Issue

  • 128 / 12

Start / End Page

  • 3886 - 3887

PubMed ID

  • 16551077

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja058516b

Language

  • eng