Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise.

Journal Article (Journal Article;Review)

The paraneoplastic syndrome of cachexia is considered a degenerative chronic inflammatory disease, being deeply related to the increase of pro-inflammatory factors, especially tumour necrosis factor alpha (TNF-alpha). It is known that the adipose tissue is affected by cachexia and contributing with the secretion of pro-inflammatory factors which reach the adjacent tissues and the circulation. The effect of pro-inflammatory factors is balanced by the effect of anti-inflammatory factors, such as interleukin 10 (IL-10). The IL-10/TNF-alpha ratio has been recently postulated as a marker for the assessment of the degree of inflammation, which correlates with disease-associated morbidity and mortality. In order to counteract inflammation in chronic disease, our group has currently adopted chronic endurance exercise in models of cancer cachexia and chronic heart failure. Since it is clear that white adipose tissue is strongly implicated in the secretion of both pro- and anti-inflammatory factors in disease, we chose to address its contribution to cachexia-related inflammation and the effect of endurance training on the capacity of cytokine expression and secretion by this tissue. Our results show an enhancement of IL-10 adipose tissue content, and increased IL-10/TNF-alpha ratio induced by endurance training. The mechanisms are discussed.

Full Text

Duke Authors

Cited Authors

  • Lira, FS; Rosa, JC; Zanchi, NE; Yamashita, AS; Lopes, RD; Lopes, AC; Batista, ML; Seelaender, M

Published Date

  • March 2009

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 71 - 75

PubMed ID

  • 19226603

Electronic International Standard Serial Number (EISSN)

  • 1099-0844

Digital Object Identifier (DOI)

  • 10.1002/cbf.1540


  • eng

Conference Location

  • England