Paraneoplastic pemphigus associated with non-Hodgkin lymphoma.

Published online

Journal Article

We report a case of a 55-year-old man who, after a 6-month history of enlargement of cervical lymph nodes, presented with multiple painful ulcerations of the oral mucosa and lips and multiple skin erosions on the trunk, back, extremities, and genitals. A lymph node biopsy was performed and revealed diffuse peripheral B-cell non-Hodgkin lymphoma. Skin biopsy revealed an acantholytic blister in the epidermis. Direct immunofluorescence showed IgG deposition in the intercellular spaces of the epidermis and linear C3 deposition in the basement-membrane zone. The indirect immunofluorescence test on rat urinary bladder epithelium was positive with a 1:320 titre. Paraneoplastic pemphigus was diagnosed based on these findings; treatment was started with cyclophosphamide, doxorubicin, vincristin and prednisone. The patient's response to treatment was poor and he developed several complications and died 2 months after diagnosis.

Full Text

Duke Authors

Cited Authors

  • Batista, MD; Takano, D; Lopes, RD; Enokihara, MMSS; Michalany, NS; de Almeida, FA

Published Date

  • June 15, 2008

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 11 -

PubMed ID

  • 18713592

Pubmed Central ID

  • 18713592

Electronic International Standard Serial Number (EISSN)

  • 1087-2108

Language

  • eng

Conference Location

  • United States